Soy milk and Sesame seeds (Phytoestrogens) Ameliorate cardiotoxcity induced by adriamycin in experimental animals

Soy milk and sesame seeds consumption has been linked to a lower incidence of chronic diseases such as cardiovascular diseases and atherosclerosis. In this study, fifty male adult albino rats (120-125 g) were divided into five experimental groups, healthy control group, positive control group injected with single dose of adriamycin ADR (10 mg/kg b.w) for induction of cardiotoxicity, group fed on diets supplemented with 20% soy milk powder after ADR injection, group fed on diets supplemented with 10% sesame seeds powder after ADR injection and group fed with diets supplemented with soy/sesame combination after injection. Results showed that, ADR injection induced cardiovascular disorders manifested by increased plasma amylase activity, troponin-T concentration, acid phosphatase activity, anticardiolipin IgM, C-reactive protein and apolipoproteinβ with highly elevated levels of triacylglycerols, total cholesterol, LDL-C and reduction of HDL-C. Observation of this study indicated that supplementation of animal diet with either soy protein or sesame seeds powder or combination of them has significant beneficial effects on ADR injected rats , through the improvement of lipid profile and reduction of elevated cardiac disease biomarkers levels. It should be noticed here that the efficiency of soy ⁄ sesame combination in reduction of adverse effects of ADR is greater than either supplement alone.